Endocrine Abstracts

Background: Despite normal aldosterone levels, diabetics often profit from the treatment with mineralocorticoid receptor (MR) antagonists (MRAs). We therefore speculated if the expression of MR and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) were changed in cells of glomerular origin under diabetic conditions and – if not - whether the synthesis of other corticosteroid hormones, that could act on MR, was increased in diabetics.Metho...

Background: Cadmium (Cd) is considered as a human carcinogen. A potential intermediate mechanism could be hormone-related by disturbing steroidogenesis in gonads and adrenal glands. We tested whether urinary Cd excretion, as a marker of long-term exposure, is associated with the urinary steroid profile in the general adult population.Methods and Findings: The Swiss Kidney Project on Genes in Hypertension (SKIPOGH) is a multicentric family-based populatio...

Background: Urinary steroid metabolomics by GC-MS is an established method in clinic and research to describe steroidogenic disorders, but normative data are scarce.Methods: The 24-hour urinary excretion of 40 steroid metabolites was measured by GC-MS in 1128 adult participants of the Swiss Kidney Project on Genes in Hypertension (SKIPOGH), a multicenter, family-based, cross-sectional study. Sex- and age-specific reference ranges were created in the unit...